Introduction Nursing is a noble profession. It is an art of providing love and care. Nurses are person who stands alone, dares to provide care in all situations, so they play a role of backbone of healthcare profession.They are prone to get occupational problems such as needle stick injury, backache, especially varicose veins. Objectives of the study: 1. To assess the prevalence of varicose vein among nurses in selected hospital. 2. To assess the knowledge and practices of nurses regarding prevention of varicose vein among the nurses in selected hospital. 3. To determine the relation between knowledge and practices regarding prevention of varicose vein among nurses. Setting of Study K.J. Somaiya hospital and research center was taken as setting of the study. Sample and Sampling Technique The sample size was 100 Nurses working in K. J. Somaiya hospital in Mumbai. Non probability convenience sampling technique was used. Tools Description of tool SECTION A:-Demographic data SECTION B: - Structured questionnaire on knowledge regarding prevention of varicose vein. SECTION C:-Structured questionnaire on practices regarding prevention of varicose vein. SECTION D: - 1) Checklist on physical assessment                       2) Plethysmograph Data Analysis: 1. AGE: Result shows that, Majority of nurses (43%) belongs to the age group 20-30 years , 29 % from 31- 40 year of age group , 22% were from 41-50 year of age group and 6% of participant belong to 51-60 year of age, respectively. 2. QUALIFICATION: It is noticed that Majority (76%) of nurses were GNM, 11% were from B.Sc. 10% were from ANM category and 3% from M.Sc. category. 3. AREA OF WORK: It reveals that the 62 % nurses were presently working in ward area, 18% were in OPD, 10% were in OT and remaining 10% were in ICU. 4. GENDER: There were 93% of female participants and only 7% of male participants. 5. KNOWLEDGE: It shows that, the majority (48 %) of nurses had average knowledge, 46 % had good knowledge and only 6% had